“Researching the Future – Inspired by Now.” Tissue engineering for regenerative dentistry is the focus of the Competence Center, which combines methods from engineering, material and life sciences.
Inspired by clinical experience, the interdisciplinary team works on developing innovative strategies for the regeneration of oral tissue such as pulp, periodontium and bone.
The Competence Center’s research focus is regenerative dentistry. For this approach, we combine methods from engineering, material and life sciences. In an interdisciplinary team we study the development of new and innovative strategies for the regeneration of oral tissue such as pulp, periodontium and bone; inspired by clinical experience for the dentistry of the future. To achieve this, the three pillars of tissue engineering play a central role: cells, biomaterials and factors.
We have experience in cultivating cells of the pulp, the periodontal ligament, and the oral soft tissue, as well as with endothelial cells and osteoclasts. Our models include monolayer and 3D models (spheroid cultures . . .). In addition, we have established the “tooth slice organ culture”. We use analyses of gene expression and translation and functional assays.
Current projects also focus on the development of innovative approaches to regenerative endodontics. What is studied are the cellular processes on which pulp regeneration is based to establish new starting points for regenerative strategies.
In addition, we currently study innovative strategies in ongoing projects to improve healing in the event of negative influencing factors such as diabetes. An approach to improve soft tissue healing and bone regeneration is offered by so-called hypoxia-mimetic agents.
The development of new therapy strategies is based on in-vitro as well as on in-vivo trials. Another focus of the Competence Center lies in the development of new in-vitro testing methods as a possible alternative to animal testing.
Hermann Agis received his Dipl.-Ing. degree in Biotechnology in 2007 from the University of Natural Resources and Life Sciences in Vienna. In 2011 he received his PhD from the Medical University of Vienna in the programme “Bones and Joint Regeneration”. From 2013 to 2014, Hermann Agis did research at the Dental School of the University of Michigan in Prof. Giannobile’s working group, where he dealt with the cellular mechanisms of oral soft tissue regeneration. In 2014 he received his venia docendi (Privatdozent) at the Medical University of Vienna. Currently he is the Head of the Competence Center for Tissue Engineering and Cell-based Therapies of the University Clinic of Dentistry of the Medical University of Vienna. In 2015, he was appointed Associate Professor. Hermann Agis’s research focuses on oral tissue engineering and the cell-biological mechanisms of regeneration. From 2010 to 2012, Hermann Agis served on the board of the Young Scientists Association (YSA) of the Medical University of Vienna. In 2011 he was elected President of YSA. He has received numerous awards, such as the Rudolf Slavicek award of the Österreichische Gesellschaft für Zahnmedizin and the Erwin Schrödinger-Stipendium of the Austrian Science Fund (ÖWF). In 2016 he was elected founding member of the ECTS Academy. Hermann Agis is active in the promotion and advancement of young scientists, as exemplified by his work in national and international mentoring programmes.
- Diana Al-Habal, graduate student
- Marwa Alsafar, graduate student
- Mara Artner, graduate student
- Peter Bauer, graduate student
- Milot Gashi, graduate student
- Alwina Schellner, graduate student
- Mariam Heitzer, guest (Austria)
- Tracy Osei-Owusu, guest (Austria)
- Charlotte Knoop, doctoral candidate
- Heinz-Dieter Müller, doctoral candidate
- Umar Alhujazy, graduate student
- Omar Hamid, graduate student
- Markus Moro, graduate student
- Eva-Maria Mozgan, graduate student
- Niloufar Pour Sadeghian, graduate student
- Peter Stanek, graduate student
- Kathrin Trimmel, graduate student
- Alina Tymoshchuk, graduate student
- Philipp Vinzenz, graduate student
- Austrian Cluster for Tissue Engineering
- Prof. William Giannobile, Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, United States of America; Department of Biomedical Engineering, College of Engineering
- Prof. Dr. med. dent. Patrick R. Schmidlin, Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, CH-8032, Zurich, Switzerland
- ECTS Academy
- Center for Medical Physics and Biomedical Engineering, Medical University of Vienna
- Center for Biomedical Research, Medical University of Vienna
- Department for Orthopaedics, Medical University of Vienna
- Department of Surgery, Division of Caridac Surgery, Medical University of Vienna
- Institute of Material Science and Technology, Vienna University of Technology
- Karl Landsteiner, University of Health
- Acmit GmbH
- PROFACTOR GmbH